Diagnostic Utility of Galectin-3 in Papillary Lesions of Thyroid

Introduction: Papillary thyroid carcinoma (PTC) is the most common malignant neoplasm of neck. Most cases PTC are diagnosed based on pathologic criteria. However, few lesions that mimic nuclear features or architecture pose diagnostic problems. projections may be encountered in benign papillary hyperplasia multinodular goiter, Hashimoto’s thyroiditis, and Graves’ disease. For this reason, approach to these challenging should include immunohistochemistry. Galectin-3(Gal-3) an immunohistochemical marker shows positivity PTC. The present study was undertaken investigate whether strong galectin-3 expression essential hallmark hyperplasia.
 Material Methods: Gal-3 sought by immunohistochemistry 33 patterns (on microscopy) specimens received at our institution. results obtained were statistically analysed.
 Result Conclusion: Of studied, 17 PTC, 16 hyperplasia. Immunohistochemical stain with Galectin -3 revealed a significant P – value, which proves tendency for higher than